The Presidio Parkway Project will reconstruct approximately 1.6 miles of highway, including seven bridges, three cut-and-cover tunnels, and an undercrossing connecting the Golden Gate Bridge to the City of San Francisco, California. The project site is approximately 5.6 miles from the San Andreas Fault, which is capable of producing magnitude 8 earthquakes. Seismic hazards include strong ground shaking, soil liquefaction, ground settlement, and lateral spreading. At the Tennessee Hollow bridge section up to 30 feet of loose sands and soft clays are present. Concerns are raised that standalone drilled piers will experience excessive lateral soil loads from liquefaction-induced lateral spreading pressure resulting in excessive pier head displacement of up to 8 inches. Ground improvement by Cement Deep Soil Mixing (CDSM) is proposed to provide additional foundation stiffness. This paper presents the methodology to: 1) assess the effectiveness of the ground improvement in resisting lateral spreading, and 2) optimize ground improvement design at individual bridge bents based on local site condition. A series of 3-D numerical analyses are conducted and the results show that drilled piers with CDSM ground improvement are capable of withstanding seismic demands from lateral spreading and the lateral pier head displacement is reduced to less than 2 inches. The adopted analytical approach is efficient at modifying design for individual bents and can be considered for future pier foundation design in seismically active areas.